A fundamental study of cell sheet treatment for gastrointestinal tract anastomotic stricture

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462039
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Ohki Takeshi 東京女子医科大学, 医学部, 講師 (90307562)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 再生医療 / 細胞シート工学 / 食道狭窄 / 吻合部狭窄 / RIC / ロボット支援手術

Outline of Final Research Achievements

Based on our knowledge and experience in clinical application of regenerative medical treatments, particularly on transplanting autologous human oral mucosal epithelial cell sheets to prevent stricture after esophageal endoscopic mucosal dissection (ESD), we conducted some basic experiments on big animals in order to develop a new treatment for patients with anastomotic stricture after surgery.
In this study, several gastrointestinal stricture models using pigs were tested. First, an open esophagogatric anastomotic stricture model was tested. However, anastomoses were not stable because the operation was highly invasive. Next, a robot-assisted esophagogatric anastomotic stricture model was tested. Anastomoses were stable, but the pigs underwent surgery were not able to eat soon. Finally, a new gastric-elevated jejunum anastomotic model was tested, and the result was satisfactory. We plan to continue our study using this gastrointestinal stricture model.

Free Research Field

消化器外科