Expression of stem cell marker CD133 in ulcerative colitis-associated colorectal cancer and dysplasia

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462046
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: The University of Tokyo
• Principal Investigator: KAZAMA SHINSUKE 東京大学, 医学部附属病院, 登録研究員 (60401098)
• Co-Investigator(Kenkyū-buntansha): YAMAGUCHI Hironori 東京大学, 医学部附属病院, 講師 (20376445) ; SUNAMI Eiji 東京大学, 医学部附属病院, 登録研究員 (70345205) ; WATANABE Toshiaki 東京大学, 医学部附属病院, 教授 (80210920)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 癌幹細胞 / CD133 / 大腸癌 / 大腸ポリープ / 潰瘍性大腸炎 / 炎症性発癌

Outline of Final Research Achievements

Immunohistochemical expression of stem cell marker CD133
1) CD133 might play an important role in both tumor development and progression in colorectal polyps. 2) CD133-positive cancer might be more aggressive than CD133-negative cancer during the process of lymph node metastasis. 3) CD133 expression in liver metastases had significant correlation with CD133 expression in primary lesion. Patients without CD133 expression in liver metastasis had significantly shorter survival, perhaps because mCD133- patients had a significantly higher rate of extrahepatic recurrence. 4) CD133 might play an important role in ulcerative colitis-associated colorectal cancer and dysplasia.

Free Research Field

癌幹細胞