Novel strategies for endogenous danger signals by a TLR7 aptamer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Nagoya University
• Principal Investigator: Uehara Keisuke 名古屋大学, 医学部附属病院, 病院講師 (50467320)
• Co-Investigator(Kenkyū-buntansha): NAGINO MASATO 名古屋大学, 医学系研究科, 教授 (20237564) ; YOKOYAMA YUKIHIRO 名古屋大学, 医学部附属病院, 講師 (80378091) ; KOKURYO TOSHIO 名古屋大学, 医学系研究科, 特任講師 (60378023) ; YOSHIOKA YUICHIRO 名古屋大学, 医学部附属病院, 助教 (50597854)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: Denger Signal

Outline of Final Research Achievements

We analyzed the expression of TLR7 and other members of the TLR family, including TLR3, TLR4, TLR5, TLR6 and TLR9, and the clinicopathological features of cholangiocarcinoma and pancreatic cancer. TLR7 was highly expressed in both cancers. In addition, TLR3, TLR4, TLR5 and TLR6 were highly expressed in both cancers.
Administration of a TLR7 agonist suppressed cell proliferation in a cholangiocarcinoma cell line and a pancreatic cancer cell line. Furthermore, a TLR7 agonist demonstrated anti-cancer effects in a xenograft mouse model. This study suggests that novel anti-cancer therapies can be developed to target TLR7.

Free Research Field

外科学