2015 Fiscal Year Final Research Report
DNA methylation profiling to evaluate the susceptibility to cancer
| Project/Area Number |
25462064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Koichi 自治医科大学, 医学部, 講師 (70332369)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 癌のかかりやすさ / DNAメチル化異常 / NAメチル化マイクロアレイ / 潰瘍性大腸炎 / 大腸癌発癌経路 |
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| Outline of Final Research Achievements |
In this study, we explore DNA methylation alterations in non-cancer tissues to evaluate the susceptibility of cancer. Methylation alterations are observed in both cancer and non-cancer tissues, so we elucidate the levels in non-cancer tissues to link with the predisposition of cancer or detection of early cancer. We identified methylation alterations in some genes decreased in cancer tissues, and explore the levels of methylation in these genes in non-cancer tissues. In ulcerative colitis, we showed that methylation alteration in non-cancer tissues could be a useful biomarker for the predisposition of colitic-cancer. Comprehensive analysis of DNA methylation array in colon cancer revealed that methylation alterations underlying colon cancer development are shared between cancer and adenomas.
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| Free Research Field |
消化器外科
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