2015 Fiscal Year Final Research Report
The impact of surfactant protein d on inflammatory bowel disease
| Project/Area Number |
25462067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSURUTA Masashi 慶應義塾大学, 医学部, 助教 (00348666)
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| Research Collaborator |
YAHAGI Masashi
TAJIMA Yuki
TOYODA Naoyoshi
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | サーファクタントプロテインd / 炎症性腸疾患 |
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| Outline of Final Research Achievements |
We focused on surfactant, pulmonary-associated protein D (SFTPD) which encodes surfactant protein D (SP-D) and evaluated the role of SP-D in ulcerative colitis (UC) in this current study. In model mouse with dextran sulfate sodium (DSS) induced colitis, the serum level of SP-D was significantly higher compared with control mouse. In addition, relatively higher level of SP-D protein was observed in mucosa of colon in the mouse with DSS induced colitis mouse. Moreover, the severity of colitis induced by DSS was mitigated in SP-D deficiency mouse compared to wild mouse. Collectively, SP-D would be associated with pathogenesis and progression of UC and could be expected a target for prevention or treatment.
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| Free Research Field |
大腸外科
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