Exploratory analysis for imaging biomarkers of hepatocellular carcinoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462082
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ban Daisuke 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (40376736)
• Co-Investigator(Kenkyū-buntansha): TANAKA Shinji 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30253420) ; TANABE Minoru 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50197513) ; MIURA Tomoya 東京医科歯科大学, 大学院医歯学総合研究科, 医員 (30618111) ; OBA Atsushi 東京医科歯科大学, 大学院医歯学総合研究科, 医員 (70740257)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肝細胞癌 / EOB-MRI / SLCO1B3 / OATP1B3

Outline of Final Research Achievements

On Gd-EOB-DTPA, although hepatocellular carcinoma (HCC) is typically lower intensity lesion in the hepatobiliary phase, cases of highly enhanced HCC (High-HCC) have been reported. This study aimed to reveal the clinicopathological and biological properties of the High-HCC. Patients who underwent curative hepatectomy as the first treatment for HCC were included. We retrospectively performed clinicopathological and global gene expression analyses.
Serum PIVKA-II levels in the High-HCC were lower, and the High-HCC were well-differentiated. Disease-free survival was prolonged in the High-HCC. Global gene expression analysis revealed the upregulated genes included those mediating normal hepatic metabolism. In addition, SLCO1B3 was upregulated in the High-HCC. This was validated by immunohistochemical analysis. We revealed HCC characteristics of hyperintensity in the hepatobiliary phase of EOB-MRI and a relatively low malignant potential.

Free Research Field

肝胆膵外科