2015 Fiscal Year Final Research Report
Effects of free fatty acid on malignant potential of hepatocellular carcinoma derived from fatty liver
| Project/Area Number |
25462085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORITA YOSHIFUMI 浜松医科大学, 医学部・附属病院, 助教 (60464129)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 肝臓外科学 |
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| Outline of Final Research Achievements |
In this study, we found the following facts: 1) hepatocellular carcinoma (HCC) derived from metabolic syndrome-related fatty liver express high amount of the enzyme Elovl-6. 2) Elovl-6 converts palmitic acid, a strong endoplasmic reticulum stressor, to harmless stearic acid. 3) HCC can survive such stressful condition via high Elovl-6 expression.
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| Free Research Field |
消化器外科学
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