Analysis of a new molecular system of branched-chain amino acids in liver damage following ischemia and re-perfusion

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462086
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Nagoya University
• Principal Investigator: Sugawara Gen 名古屋大学, 医学部附属病院, 病院講師 (00402587)
• Co-Investigator(Kenkyū-buntansha): NAGINO MASATO 名古屋大学, 医学系研究科, 教授 (20237564) ; YOKOYAMA YUKIHIRO 名古屋大学, 医学部附属病院, 講師 (80378091) ; KOKURYO TOSHIO 名古屋大学, 医学系研究科, 特任講師 (60378023) ; ITATSU KEITA 名古屋大学, 医学系研究科, 寄附講座助教 (90534842)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肝虚血再灌流障害 / 分枝鎖アミノ酸

Outline of Final Research Achievements

BCAAs (branched-chain amino acids) suppress inflammatory factors, such as IL-6 (interleukin-6), TNFα (tumor necrosis factor alpha), ET1 (endothelin 1), ICAM (intercellular adhesion molecule) and VCAM (vascular cell adhesion molecule), in liver tissue of a model of ischemia / re-perfusion (I/R) injury.
A TLR4 inhibitor prevented liver damage in an ischemia / re-perfusion (I/R) injury model with additional administration of 5-FU. A TLR4 inhibitor also prevented liver damage in a bile duct ligation I/R liver injury model.

Free Research Field

外科学