2015 Fiscal Year Final Research Report
Regulation of aged liver regenerative disorder focused of epigenetic changes
Project/Area Number |
25462091
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | The University of Tokushima |
Principal Investigator |
MORINE Yuji 徳島大学, 大学院医歯薬学研究部, 講師 (60398021)
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Co-Investigator(Kenkyū-buntansha) |
SHIMADA Mitsuo 徳島大学, 大学院医歯薬学研究部, 教授 (10216070)
IMURA Satoru 徳島大学, 病院, 特任教授 (90380021)
IKEMOTO Tetsuya 徳島大学, 大学院医歯薬学研究部, 助教 (20398019)
UTSUNOMIYA Toru 徳島大学, 大学院医歯薬学研究部, 准教授 (30304801)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | Epigenetics / HDAC / 肝再生 / 加齢 / 肝切除 |
Outline of Final Research Achievements |
Mechanism of the decreased regenerative capacity of aged liver after hepatectemy and its regulation focused on epigenetic changes were elucidated in this study. In aged liver, the down-regulated of cell cycle and up -regulated of apoptosis-related genes during liver regeneration after hepatectomy were demonstrated. Also the epigenetic regulation with HDAC inhibitor up-regulated cell cycle related genes and differentiation related genes, after hepatectomy resulted in increase of liver regeneration and decrease of liver injury.
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Free Research Field |
消化器外科
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