Clinicopathologic and genetic analysis of pancreatic neuroendocrine tumor (PNETs)

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462115
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kagawa University
• Principal Investigator: Okano Keiichi 香川大学, 医学部附属病院, 准教授 (20314916)
• Co-Investigator(Kenkyū-buntansha): YACHIDA Shinichi 独立行政法人国立がん研究センター, 研究所, ユニット長 (20359920) ; SUZUKI Yasuyuki 香川大学, 医学部, 教授 (40304092)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 膵神経内分泌腫瘍 / TSC2 / P53 / DAXX / ATRX

Outline of Final Research Achievements

The number of patients with pancreatic neuroendocrine tumor (PNETs) has been increased. The genetic and clinicopathologic features are still unclear. In this study, we analyzed the genetic changes and clinicopathological features of PNETs. The specimens from 88 patients with PNETs (multicenter study) were classified according to the 2010WHO classification. Five major genes of PNETs (DAXX, ATRX, MEN1, TSC2, PTEN) were examined. The immunohistochemical staining results revealed that significant association of ATRX and liver metastasis, TSC2 (Tuberin) and post-operative recurrence. The p53 abnormality showed significant correlation with PNETs Grade classification (G1/2).

Free Research Field

消化器外科