2015 Fiscal Year Final Research Report
Development of Local Treatment for Bile Duct Carcinoma by PDT Applying the New Glucose-Conjugated Chlorin
| Project/Area Number |
25462120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Miyazaki (2015)
Nagasaki University (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIYOSHI Masahide 宮崎大学, 医学部, 助教 (60381117)
YANO Koichi 宮崎大学, 医学部, 助教 (30627344)
ABO Takahumi 長崎大学, 病院(医学系), 助教 (70404267)
NAGAYASU Takeshi 長崎大学, 医歯薬総合研究科(医学系), 教授 (80284686)
ISOMOTO Hajime 長崎大学, 病院(医学系), 准教授 (90322304)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 光線力学的療法 / 糖鎖連結クロリン / 胆管癌 |
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| Outline of Final Research Achievements |
The effect of Photodynamic therapy can be expected as an adjunct therapy for unresectable cholangiocellular carcinoma. On the other hand, there are side effects such as ray hypersensitivity. Accordingly, the development of a new photosensitizer of high anti-cancer effects and high tumor specificity is expected. We compared the effects of photodynamic therapy for bile duct carcinoma using glucose-conjugated chlorine(G-PDT), which is expected as a new photosensitizer and talaporfin sodium(L-PDT), which is a photosensitizer that is currentry used.
In experiments with cells, apoptotic induction rate in the G-PDT showed more increased rate in comparison with that in the L-PDT. Cytocidal effect in the G-PDT was higher than in the L-PDT. In animal experiments, A treatment of the new G-PDT showed the high inhibition of tumor growth in the treatment of bile duct carcinoma cells.
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| Free Research Field |
消化器外科
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