Development of repairing procedure using temperature responsive polymer for post-infarction ventricular septal perforation

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462135
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Nagoya University
• Principal Investigator: Oshima Hideki 名古屋大学, 医学系研究科, 准教授 (40378188)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 心筋梗塞 / 心室中隔穿孔 / 温度応答性ポリマー

Outline of Final Research Achievements

We developed the surgical method using the temperature-responsive polymer to repair post MI ventricular septal perforation more surely. We sew a patch to repair VSP, but it is likely that suture-lines will be ruptured because infarction cardiac muscle is very fragile tissue.
In this study, we restored the tissue intensity by injecting a temperature-responsive polymer into infarction cardiac muscle, and improved the durability of damaged tissue against the stress of surgical suturing.In the in-vitro study, it became clear that tissue intensity of 3 times was obtained by injecting poly (N-isopropyl acrylic amide) (PNIPAM) polymer. In the rat MI model, thinning and tear injury of the cardiac tissue over time at the patch-suture sites were inhibited when we injected the polymer and sewed a ePTFE patch to rat infarction cardiac muscle.

Free Research Field

医歯薬学