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2016 Fiscal Year Final Research Report

Development of repairing procedure using temperature responsive polymer for post-infarction ventricular septal perforation

Research Project

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Project/Area Number 25462135
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionNagoya University

Principal Investigator

Oshima Hideki  名古屋大学, 医学系研究科, 准教授 (40378188)

Project Period (FY) 2013-04-01 – 2017-03-31
Keywords心筋梗塞 / 心室中隔穿孔 / 温度応答性ポリマー
Outline of Final Research Achievements

We developed the surgical method using the temperature-responsive polymer to repair post MI ventricular septal perforation more surely. We sew a patch to repair VSP, but it is likely that suture-lines will be ruptured because infarction cardiac muscle is very fragile tissue.
In this study, we restored the tissue intensity by injecting a temperature-responsive polymer into infarction cardiac muscle, and improved the durability of damaged tissue against the stress of surgical suturing.In the in-vitro study, it became clear that tissue intensity of 3 times was obtained by injecting poly (N-isopropyl acrylic amide) (PNIPAM) polymer. In the rat MI model, thinning and tear injury of the cardiac tissue over time at the patch-suture sites were inhibited when we injected the polymer and sewed a ePTFE patch to rat infarction cardiac muscle.

Free Research Field

医歯薬学

URL: 

Published: 2018-03-22  

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