Thin expanded polytetrafluoroethylene pulmonary valve and polytetrafluoroethylene conduit with bulging sinus

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462140
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Yamagishi Masaaki 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (40182422)
• Co-Investigator(Kenkyū-buntansha): Maeda Yoshinobu 京都府立医科大学, 大学院医学研究科, 助教 (20438203) ; Miyazaki Takako 京都府立医科大学, 大学院医学研究科, 助教 (90405291)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肺動脈弁 / 右室流出路形成 / ePTFE / 人工血管

Outline of Final Research Achievements

We performed clinical use of newly developed tricuspid fan-shaped pulmonary valve using the ultra-thin ePTFE membrane and ePTEF conduit with bulging sinus for right ventricular outflow reconstruction. The diameter of the conduit was 16.4±4.0mm. The pressure gradient was 13.2±8.6mmHg in the large-diameter group (more than 18mm) and 16.3±10.4mmHg in the small diameter group (16mm or less). It was suggested that the ultra-thin ePTFE membrane valve effective technology for preventing stenosis. Pulmonary regurgitation significantly increased in a large-diameter (22, 24mm) conduit.

Free Research Field

心臓血管外科学