Role of neural crest cells in bicuspic aortic valve

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462147
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Yamazaki Gakuen University (2015); Tokyo Women's Medical University (2013)
• Principal Investigator: Miyagawa-Tomita Sachiko ヤマザキ学園大学, 公私立大学の部局等, 教授 (40231451)
• Research Collaborator: NAGAO Hiroaki 東京女子医科大学, 医学部, 技師 ; MAEDA Kazuhiro 東京女子医科大学, 医学部, 大学院生 ; SEYA Daiki 東京大学, 大学院医学研究科, 大学院生 ; MARUYAMA Kazuaki 東京大学, 大学院医学研究科, 大学院生 ; KURIHARA Hiroki 東京大学, 大学院医学研究科, 教授
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 大動脈弁 / 二弁性大動脈弁 / 神経堤細胞 / １細胞解析

Outline of Final Research Achievements

The aortic valve which consists of three valve leaflets prevents regurgitant blood flow at the outflow tract of the left ventricle. Bicuspid aortic valve is the most common congenital heart defect, occurring in 0.5% to 2% of the general population, with a higher prevalence in men. Mature aortic valves are stratified into extracellular matrix layers rich in elastin (ventricularis), proteoglycan (spongiosa) and collagen (fibrosa).　Formation of the aortic valve is involved in endocardial cells, second heart field derived cells, and neural crest derived cells. In our research, postotic and preotic neural crest cells were shown distinctive patterns in the aortic valve leaflets. And we confirmed that neural crest cells were involved in the development of the ascending aorta.

Free Research Field

循環器発生学