Experimental analysis of continuous epidural cooling against spinal cord injury

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462167
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Keio University
• Principal Investigator: yoshitake akihiro 慶應義塾大学, 医学部, 講師 (70327550)
• Co-Investigator(Kenkyū-buntansha): Shimizu Hideyuki 慶應義塾大学, 医学部, 教授 (50226247) ; Takaki Hidenobu 東京歯科大学, 歯学部, 助教 (20594683)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胸腹部大動脈瘤 / 脊髄保護 / 硬膜外クーリング

Outline of Final Research Achievements

Eighteen pigs underwent thoracic aortic double clamping for 35 minutes. These are divided into three groups, Gourp A(cooling temperature; 4℃), Group B (20℃), and Goup C(control). Mean time from aortic crossclamping to onset of MEP loss was significantly longer in group A and B than group C. Group A and group Bshowed significantly better neurologic function than that of group C. In group A and group B, motor neurons had a nearly normal appearance, with minimal eosinophilic change in the cytoplasm. Group C motor neurons showed acute necrotic changes. Degenerating neurons were swollen or shrunken.

Free Research Field

心臓血管外科