2016 Fiscal Year Final Research Report
Development of a tissue-engineering, small-caliber vascular graft
| Project/Area Number |
25462168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 人工血管 / フィブロネクチン / ヘパリン / 共有結合 |
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| Outline of Final Research Achievements |
Tissue engineering has emerged as a promising approach to generate biologically functioning prosthetic vascular grafts exhibiting rapid neointima formation without subsequent degenerative change. We demonstrated that, in a canine model, covalent bonding of fibronectin enhanced the healing of small-caliber, long-fibril ePTFE vascular grafts. However, in a pig model, the fibronectin-bonded grafts did not exhibit powerful antithrombogenicity by the luminal endothelial cells until graft healing was completed, and therefore subsequent graft thrombosis occurred. We therefore hypothesized that, with further modifications by an anti-thrombotic molecule coating, covalent bonding of fibronectin may have great potential in the development of better small-caliber arterial prosthetic grafts.We could determine the optimal condition of covalent-bonding of fibronectin as well as heparin, and are continuing to develop the optimal method of simultaneous covalent-bonding of fibronectin and heparin.
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| Free Research Field |
血管外科
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