2016 Fiscal Year Final Research Report
New molecular target for lung cancer using PPAR-gamma
| Project/Area Number |
25462175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyoto Prefectural University of Medicine (2015-2016)
Osaka University (2013) |
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Principal Investigator |
Inoue Masayoshi 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10379232)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 肺癌 / PPAR-gamma / 上皮間葉移行 |
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| Outline of Final Research Achievements |
PPAR-gamma, an intra-nuclear protein, has a potential role for anti-inflammation and anti-tumor effect. We assessed the anti-tumor role caused by the control of epithelial-mesenchymal transition using PPAR-gamma agonists in lung cancer. The epithelial-mesenchymal transition was slightly suppressed by tBHQ, an activator of Nrf2 which regulates PPAR-gamma expression in vitro. Additionally, pirfenidone, an anti-fibrotic agent, showed suppression both of epithelial-mesenchymal transition and cancer cell growth.
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| Free Research Field |
呼吸器外科
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