2015 Fiscal Year Final Research Report
Mechanism identification and Developing a novel method for therapy against lung cancer invasion via cancer-associated fibroblasts in pulmonary emphysema
Project/Area Number |
25462177
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory surgery
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Research Institution | Yamaguchi University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NISHIMOTO Arata 山口大学, 医学部附属病院, 助教 (90396325)
UEDA Kazuhiro 山口大学, 医学部附属病院, 講師 (90420520)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 肺癌 / 肺気腫 / 癌関連線維芽細胞 |
Outline of Final Research Achievements |
To evaluate whether cancer-related fibroblasts are useful as a novel target for lung cancer therapy, we aimed to elucidate the characteristic of cancer-related fibroblasts in lung cancer with pulmonary emphysema and the role of cancer-related fibroblasts in lung cancer progression in the emphysema lung. We manufactured Lewis lung cancer xenograft in murine model with pulmonary emphysema and tried to identify cancer-related fibroblasts in the emphysema lung resected from this model by detecting FAP and alpha-SMA-positive cells using FACS analysis.
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Free Research Field |
呼吸器外科
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