The establishment of multimodal therapy of thymic epithelial tumors with podoplanin expression

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462194
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Toneyama National Hospital
• Principal Investigator: Susaki Yoshiyuki 独立行政法人国立病院機構刀根山病院(臨床研究部), その他部局等, 研究員 (10528649)
• Co-Investigator(Kenkyū-buntansha): Okumura Meinoshin 大阪大学, 医学系研究科, 教授 (40252647) ; Minami Masato 大阪大学, 医学部附属病院, 准教授 (10240847) ; Inoue Masayoshi 京都府立大学, 医学系研究科, 教授 (10379232) ; Shintani Yasushi 大阪大学, 医学系研究科, 准教授 (90572983) ; Nakagiri Tomoyuki 大阪大学, 医学系研究科, 研究員 (70528710)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: podoplanin / 胸腺癌 / 胸腺腫 / CTOS

Outline of Final Research Achievements

Podoplanin expression was examined immunohistochmically in invasive thymomas and thymic carcinomas.Regarding disease-free survival,podoplanin-positive cases had significantly poorer prognsis than podolanin-negative cases. Podoplanin expession was obseved in disseminated lesions frequently.These data indicated that podoplanin was associated with the progress of invasion of thymomas. We established the thymic carcinoma cell line, and clarify podoplanin expression in thymic carcinoma cells correlate with Epithelial Mesenchymal transition.

Free Research Field

呼吸器外科