New treatment strategy for malignant pleural mesothelioma focusing on microRNAs related to cancer stem cell makers

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462195
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Okayama University
• Principal Investigator: SOH JUNICHI 岡山大学, 大学病院, 講師 (90559890)
• Co-Investigator(Kenkyū-buntansha): MIYOSHI Shinichiro 岡山大学, 医歯(薬)学総合研究科, 教授 (00190827) ; TSUKUDA Kazunori 岡山大学, 大学病院, 講師 (20346430) ; TOYOOKA Shinichi 岡山大学, 医歯(薬)学総合研究科, 教授 (30397880) ; YAMAMOTO Hiromasa 岡山大学, 大学病院, 助教 (40467733) ; ASANO Hiroaki 岡山大学, 大学病院, 助教 (70534775)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 悪性胸膜中皮腫 / 癌幹細胞 / マイクロRNA

Outline of Final Research Achievements

Malignant pleural mesothelioma (MPM) is a well-known tumor which shows treatment resistance and dismal prognosis. There is a need to resolve the cause of this disease and to develop a new treatment. We investigated the cause of MPM and the new treatment strategy by focusing on the cancer stem cell and micro-RNA (moRNA) related to cancer stem cell markers. We performed a comprehensive miRNA expression analysis to find the families of miRNA-34 and miRNA-200 as candidate of cancer stem cell related miRNA of MPM. We analyzed the effect of transduction of these miRNAs on expression of cancer stem cell related makers, cell viability, and drug sensitivity. We are investigating the new candidates of miRNAs relaeted to cancer stem cell of MPM by cell sorting method.

Free Research Field

胸部悪性腫瘍