Metabolome analysis of hypoxia mechanism in malignant pleural mesothelioma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462196
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Hiroshima University
• Principal Investigator: Miyata Yoshihiro 広島大学, 原爆放射線医科学研究所, 准教授 (50397965)
• Co-Investigator(Kenkyū-buntansha): OKADA MORIHITO 広島大学, 原爆放射線医科学研究所, 教授 (70446045)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 悪性胸膜中皮腫 / 低酸素 / メタボローム

Outline of Final Research Achievements

We hypothesized that hypoxia induced by tumor proliferation may play an important role in malignant pleural mesothelioma (MPM). We evaluate the relevance of several biomarkers to predict the prognosis of MPM. There was no correlation of HIF1α and GLUT1 expressions with clinical outcome. .DHFR expression significantly associated with survival after induction chemotherapy followed by surgery. When biopsy and surgeries were compared per patient, merlin expression levels are the same before and after chemotherapy (R2=0.5126). Merlin low patients (34%) had significantly good prognosis. These molecules could be good predictors to decide the treatment strategy for MPM.

Free Research Field

呼吸器外科学