The search for effective intrapleural therapies and new biomarkers of mesothelioma.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462199
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kitasato University
• Principal Investigator: Shiomi Kazu 北里大学, 医学部, 講師 (50398682)
• Co-Investigator(Kenkyū-buntansha): SATO Yuichi 北里大学, 医療衛生学部, 教授 (30178793) ; TAMAUCHI Hidekazu 愛媛県立医療技術大学, 保健科学部, 教授 (60188414) ; SATOH Yukitoshi 北里大学, 医学部, 教授 (90321637) ; ESHIMA Koji 北里大学, 医学部, 准教授 (30327324)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 中皮腫 / 胸腔内治療 / バイオマーカー

Outline of Final Research Achievements

We conducted basic experiments with the aim of developing effective intrapleural therapies and finding new biomarkers for mesothelioma. We made two mesothelioma mouse models with transplanted mouse cancer cell lines intrapleurally or subcutaneously. Then, using these models, we found an excellent combination therapy of an anti-cancer agent (Gemcitabine), an anti-PD-1 antibody and anti-CTLA4 antibody which eradicated the tumors. With regard to searching new biomarkers using two proteomic analysis methods, we found twenty candidate proteins. Now, we are testing their effectiveness.

Free Research Field

呼吸器外科