Development of evaluation methods of the real-time cerebral blood flow in the internal carotid artery occlusion

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462204
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: Sato Kenichi 東北大学, 医学(系)研究科(研究院), 非常勤講師 (90634973)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Atsuhiro 東北大学, 大学病院, 助教 (10447162) ; WASHIO Toshikatsu 国立研究開発法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (40358370) ; ARAHUNE Tatsuhiko 東京電気大学, 理工学部, 助教 (50376597)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脳血流 / 大脳半球循環時間 / クモ膜下出血 / 脳血管攣縮 / 遅発性脳虚血 / 内頚動脈閉塞

Outline of Final Research Achievements

Balloon occlusion test has been used for the evaluation of the tolerance against unilateral internal carotid artery occlusion. The conventional balloon occlusion test has required the measurement of the cerebral blood flow and clinical condition during the occlusion of the internal carotid artery. In this research, we elucidated a strong correlation between the angiographic circulation time and the cerebral blood flow during the balloon occlusion test. This result would make the balloon occlusion test safer and easier. This method enables us to estimate the tissue blood flow according to findings of the catheter angiogram and would be useful for the understanding pathophysiology of diseases in other tissues and organs.
Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage in one of poor prognostic factor. In this research, we revealed the usefulness of the real-time cerebral blood flow measurement for the prevention of the delayed cerebral ischemia.

Free Research Field

脳神経外科学