2015 Fiscal Year Final Research Report
Analysis of magnesium-induced vasodilation and dysfunction in cerebral penetrating arterioles after subarachnoid hemorrhage
| Project/Area Number |
25462210
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HORIUCHI Tetsuyoshi 信州大学, 学術研究院医学系, 准教授 (40303466)
|
|---|
| Research Collaborator |
Dietrich Hans H.
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | マグネシウム / 脳細動脈 / くも膜下出血 / 脳血管攣縮 |
|---|
| Outline of Final Research Achievements |
We investigated in cerebral penetrating arterioles the signaling mechanisms and dose-dependency of extracellular magnesium-induced vasodilation and also its vasodilatory effects in vessels preconstricted with agonists associated with delayed cerebral vasospasm following subarachnoid hemorrhage (SAH).
Male rat penetrating arterioles were cannulated. Their internal diameters were monitored.
Magnesium induced a concentration- and smooth muscle cell-dependent dilation in cerebral penetrating arterioles. Calcium-sensitive potassium channels of smooth muscle cells may play a key role in magnesium-induced vasodilation. Magnesium also dilated endothelium-impaired vessels as well as vessels preconstricted with spasmogenic agonists. These results provide a fundamental background for the clinical use of magnesium, especially in treatment against delayed cerebral ischemia or vasospasm following SAH.
|
| Free Research Field |
脳神経外科
|
