Neuroporotective effect of subthalamic nucleus deep brain stimulation in Parkinson's disease

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462211
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Nozaki Takao 浜松医科大学, 医学部附属病院, 助教 (10598494)
• Co-Investigator(Kenkyū-buntansha): SUGIYAMA Kenji 浜松医科大学, 医学部, 準教授 (00235904)
• Co-Investigator(Renkei-kenkyūsha): OUCHI Yasuomi 浜松医科大学, 医学部, 教授 (40436978)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: パーキンソン病 / 視床下核脳深部刺激療法 / 神経炎症反応 / ミクログリア / 神経保護効果

Outline of Final Research Achievements

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in ameliorating the symotpms of Parkinson’s disease (PD). Recently, DBS is considered to have neuroprotective effect in PD. We are now focuing on the activation of microglia, namely, neuroinflammation. Previously, we had reported the increase of microglial activation in early PD. In this study, we have performed [11C]713DPA-PET, which is the tracer of microglia. The preliminary evaluation showed that the postoperative activations of microglia were relatively low compared with preoperative ones. We are currently analyzing the details of the data.

Free Research Field

機能的脳神経外科