The evaluation of cerebral protective effect of hypothermia therapy for traumatic brain injury patients with evacuated mass lesions

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462219
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Yamaguchi University
• Principal Investigator: SUEHIRO Eiichi 山口大学, 医学部附属病院, 助教 (10363110)
• Co-Investigator(Kenkyū-buntansha): TSURUTA Ryousuke 山口大学, 大学院医学系研究科, 教授 (30263768) ; ODA Yasutaka 山口大学, 大学院医学系研究科, 准教授 (40397998) ; KOIZUMI Hiroyasu 山口大学, 医学部, 特別医学研究員 (40423389) ; FUJITA Motoki 山口大学, 大学院医学系研究科, 助教 (50380001) ; SUZUKI Michiyasu 山口大学, 大学院医学系研究科, 教授 (80196873)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 頭部外傷 / 脳低温療法 / バイオマーカー / フリーラジカル / 神経集中治療

Outline of Final Research Achievements

The cerebral protective effect of hypothermia　therapy was investigated in patients with head injury who had traumatic intracranial hematoma requiring craniotomy. Reactive oxygen production upon decompressive craniectomy promotes brain damage and was investigated using a biomarker. Only 13 patients met the inclusion criteria over a 3-year period due to the recent decrease in patients with head injury. The favorable outcome rates were 100% (5/5) in the hypothermia group and 62.5% (5/8) in the normothermia group, but the difference was not significant. There was no reactive oxygen production upon decompressive craniectomy based on the biomarker. The small number of patients prevented observation of the efficacy of hypothermia therapy. There is a need to examine more cases through performance of a multicenter study.

Free Research Field

脳神経外傷