2015 Fiscal Year Final Research Report
Study for pathogenesis of Moyamoya disease using induced pluripotent stem cells
| Project/Area Number |
25462222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
江良 択実 熊本大学, 発生医学研究所, 教授 (00273706)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脳血管障害 / 人工多能性幹細胞 / 細胞外マトリックス / 血流ストレス |
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| Outline of Final Research Achievements |
We analyzed the autopsy specimen of moyamoya disease by using immunohistochemistry methods. The surface matrix of moyamoya disease patient contains less amount of hyaruronan and chondroitin sulfate, thus the endothelial cells of moyamoya disease are vulnerable to shear stress of blood stream. As a result, repair cells are invade into the vascular wall and produce excessive amount of hyarulonan, then cause vascular occulusion.
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| Free Research Field |
小児神経学
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