2015 Fiscal Year Final Research Report
The basic research for the relationship of chronic inflammation and pathogenesis of cerebral aneurysm
| Project/Area Number |
25462224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURATSU Junichi 熊本大学, 大学院生命科学研究部, 教授 (20145296)
OHMORI Yuki 熊本大学, 医学部附属病院, 特任助教 (60599116)
MIYATA Keishi 熊本大学, 大学院生命科学研究部, 特任准教授 (50398228)
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| Co-Investigator(Renkei-kenkyūsha) |
OIKE Yuichi 熊本大学, 大学院生命科学研究部, 教授 (90312321)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 慢性炎症 / 動脈瘤 / angptl2 |
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| Outline of Final Research Achievements |
Our study shows the expression of macrophage in the cerebral aneurysm (CA) wall and suggests that is involved in CA pathogenesis. Chronic inflammation due to Angptl2 expression is thought to be the main cause of CA rupture. But our study does not suggests the correlation between Angptl2 expression and CA incidence in mouse aneurysm model.
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| Free Research Field |
脳血管障害
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