Analysis of the neural network plasticity in the human basal ganglia disease using non-invasive molecular image

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462229
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Sasajima Hiroyasu 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (80196188)
• Co-Investigator(Kenkyū-buntansha): OWADA Kei 京都府立医科大学, 医学研究科, 助教 (80332948) ; MINEURA Katsuyoshi 京都府立医科大学, 医学研究科, 教授 (70134103)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 大脳基底核 / 神経画像診断学 / FDG- PET / Fluorodopa-PET / DAG-PET / 神経回路可塑性

Outline of Final Research Achievements

We analyzed a functional change of the neural network and neural plasticity in the　human　basal　ganglia　disease　using　PET　from　the　viewpoint　of　signal transduction syatem. In stroke patients, because uptake of DAG was increased to prefrontal and parietal area for only subacute phase and attenuated after symptom improvement, it was estimated that this phenomenon reflected a plasticity mechanism. In two cases of bobble-head doll syndrome known as cranio-cervical dyskinesis, we reviewed that the presynaptic function of dopamine cells in the bilateral striatum was enhanced by fluorodopa-PET study. The suppression of output systems of basal ganglia caused by hyperfunction of the presynaptic dopaminergic cells may play an important role of the occurrence of bobble-head doll movement. The biochemical information obtained by the PET studies contributes to mechanism elucidation of the neural plasticity in the human basal ganglia disease.

Free Research Field

脳神経外科学