Cerebral microcirculatory disturbance and astrocyte

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462233
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Institute of Physical and Chemical Research (2016); Jichi Medical University (2013, 2015)
• Principal Investigator: Ishikawa Mami 国立研究開発法人理化学研究所, 脳科学総合研究センター, 客員研究員 (60212859)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: くも膜下出血 / 脳虚血 / アストロサイト / Ca / 白血球

Outline of Final Research Achievements

The cortical microcirculation was observed in vivo at the time of SAH induction at the skull base or cerebral ischemia induction, using a two-photon laser scanning microscopy with line-scan analysis. SAH caused sudden worsening of the cortical arteriolar velocity and flow at the onset. The neurovascular unit cannot function enough to maintain cortical microcirculatory flow in the super acute phase of SAH.
Increased intracranial pressure after subarachnoid hemorrhage (SAH) causes extensive brain ischemia and results in worsening the clinical status. SAH caused sudden worsening of cortical microcirculation at the onset. The leukocyte plugging in capillaries is one of reasons why cortical microcirculation is aggravated after SAH.
I first observed the cortical microcirculation in the super acute phase of SAH with a two-photon laser scanning microscopy and reported the cortical microcirculatory disturbance, autoregulatory dilatory response and the neurovascular dysfunction after SAH.

Free Research Field

脳微小循環