Evaluation of the regenerative cell therapy for cerebral infarction with our functional endothelial progenitor cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462234
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Dokkyo Medical University
• Principal Investigator: suzuki kensuke 獨協医科大学, 医学部, 准教授 (20400674)
• Co-Investigator(Kenkyū-buntansha): HYODO Akio 獨協医科大学, 医学部, 教授 (40167606) ; TANAKA Yoshihiro 獨協医科大学, 医学部, 講師 (90316571) ; NAGAISHI Masaya 獨協医科大学, 医学部, 講師 (40364632) ; SHIMIZU Nobuyuki 獨協医科大学, 医学部, 講師 (70636654) ; TAKANO Issei 獨協医科大学, 医学部, 助教 (20364630) ; SUZUKI Ryotaro 獨協医科大学, 医学部, 助教 (10552309) ; SUGIURA Yoshiki 獨協医科大学, 医学部, 助教 (90636648) ; TAKIGAWA Tomoji 筑波大学, 医学医療系, 講師 (60450227) ; MARUSHIMA Aiki 筑波大学, 医学医療系, 講師 (40722525)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脳梗塞 / 動物実験 / 血管内皮前駆細胞 / 再生医療

Outline of Final Research Achievements

Regenerative therapy has been prospected for new treatment also for cerebral infarction. In this study, we researched the effect of our original endothelial progenitor cells with low aldehyde dehydrogenase (Alde-Low EPC) for cerebral infarction in the rat models.The results was follow; 1.Injection of Alde-Low EPC made the volume of cerebral infarction smaller.2.Alde-Low EPC accumulated in infarction area and showed their effect. 3.Also after 14 days of infarction, we confirmed the effect of Alde-Low EPC for cerebral infarction. More studies which reveal the mechanism of Alde-Low EPC function in cerebral infarction is needed. However, we confirmed that Alde-Low EPC accumulated and effected within 24 hours and their effects continued also after 2 weeks. But we could not find the optimal way for clinical use of these cells. In the next step, we will investigate about mesenchymal stem cells which can be extracted from patients’ fat tissue in the same way in this study.

Free Research Field

脳神経外科学　脳卒中