Effect of radiosurgery and transarterial embolization on the endothelium of cerebral AVMs

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462235
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Saitama Medical University
• Principal Investigator: Kurita Hiroki 埼玉医科大学, 医学部, 教授 (70262003)
• Co-Investigator(Kenkyū-buntansha): OOIGAWA Hidetoshi 埼玉医科大学, 医学部, 准教授 (60626513) ; HAYASHI Takeshi 埼玉医科大学, 医学部, 教授 (40314679) ; TAKEDA Ririko 埼玉医科大学, 医学部, 講師 (70649847) ; NAKAJIMA Hiroyuki 埼玉医科大学, 医学部, 講師 (50406469) ; YOSHIKAWA Shinichiro 埼玉医科大学, 医学部, 助教 (80649525) ; IKEDA Toshiki 埼玉医科大学, 医学部, 講師 (90406968) ; KIKKAWA Yuichiro 埼玉医科大学, 医学部, 講師 (80423515)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脳動静脈奇形 / radiosurgery / 血管内塞栓術 / ＶＥＧＦ

Outline of Final Research Achievements

Effect of irradiation or trans-arterial embolization on endothelium of cerebral arteriovenous malformations remains to be elucidated. We clarified the significant role of vascular endothelial growth factor in proliferative vasculopathy following those interventions in rat cerebral arteriovenous malformation model and surgical specimens.

Free Research Field

脳血管障害学