Suicide gene theraphy for malignant glioma using induced pluripotent stem cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462252
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Amano Shinji 浜松医科大学, 医学部, 特任研究員 (70464138)
• Co-Investigator(Kenkyū-buntansha): Namba Hiroki 浜松医科大学, 医学部, 教授 (60198405)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 自殺遺伝子療法 / iPS細胞 / bystander効果 / mesenchymal stem cell

Outline of Final Research Achievements

Suicide gene theraphy for malignant glioma using induced pluripotent stem cells(iPS cells) was studied. Mouse iPS cells indicated accumulation in a various glioma cell lines. The bystander effect with the glioma cells didn't give us the good effect, because cell contact is obstructed by speed of the iPS cell division and the colony formation.
When I made a mouse iPS cell differentiate into mesenchymal stem cell (MSC), and it was considered, good anti-tumor effect was admitted. The MELK gene which participates in colony formation was restrained in SiomycinA, but the effect was impartial. MELK genetic restraint could see reinforcement of the effect to cancer stem cell.

Free Research Field

脳腫瘍学