2015 Fiscal Year Final Research Report
Molecular analysis of invasion and angiogenesis of malignant glioma
| Project/Area Number |
25462261
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUROZUMI Kazuhiko 岡山大学, 大学病院, 講師 (20509608)
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| Co-Investigator(Renkei-kenkyūsha) |
DATE Isao 岡山大学, 大学院医歯薬学総合研究科, 教授 (70236785)
YASUHARA Takao 岡山大学, 大学院医歯薬学総合研究科, 講師 (50457214)
KAMEDA Masahiro 岡山大学, 大学院医歯薬学総合研究科, 助教 (50586427)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脳腫瘍学 / 血管新生―浸潤シフト / グリオーマ / 浸潤 / 血管新生 |
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| Outline of Final Research Achievements |
To investigate angiogenesis and invasion of malignant glioma, we conducted microarray analysis of our original glioma models. As a result, we found FGF13 as a candidate molecule for angiogenesis-independent invasion. Also, we analyzed molecular function of FGF13 by using our glioma models. FGF13 might contribute to angiogenesis-independent invasion by controlling cellular cytoskeleton.
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| Free Research Field |
医歯薬学、外科系臨床医学、脳神経外科学
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