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2015 Fiscal Year Final Research Report

Imaging of malignant brain tumor after treatment with VEGF inhibitor

Research Project

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Project/Area Number 25462262
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionHiroshima University

Principal Investigator

Yamasaki Fumiyuki  広島大学, 大学病院, 講師 (60444692)

Co-Investigator(Kenkyū-buntansha) Kurisu Kaoru  広島大学, 医歯薬保健学研究院, 教授 (70201473)
Sugiyama Kazuhiko  広島大学, 病院, 教授 (30243554)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsglioblastoma / malignant lymphoma / DWI / 1HMRS / VEGF / cavernous angioma / cranial irradiation
Outline of Final Research Achievements

We investigated the risk factors for brain apoplexy after VEGF treatment. Our study indicated that hemorrhagic apoplexy developed within 3 months、while thromboembolic apoplexy develop 6 months after VEGF treatment, and related to risk factor of brain infarction including hypertension. Our study revealed that the relationship between tumor location and the lesion of DWI high intensity was important for differentiation between true- and pseudo-response after bevacizumab treatment. Large lipid peaks on 1H-MRS images of tumors without central necrosis were characteristic of malignant lymphomas. Conversely, small or absent lipid peaks in intraaxial tumors without central necrosis were strongly suggestive of glioma. Patients who underwent radiation therapy with primitive neuroectodermal tumors or pineoblastoma developed Zabramski type 1 and 2 CVA significantly earlier than did medulloblastoma patients.

Free Research Field

Neurosurgery

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Published: 2017-05-10  

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