Verification of ventricular enlargement mechanism in idiopathic normal pressure hydrocephalus using with hypertensive rat

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462263
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Yamaguchi University
• Principal Investigator: NOMURA Sadahiro 山口大学, 医学(系)研究科(研究院), 准教授 (20343296)
• Co-Investigator(Kenkyū-buntansha): SHIRAO Satoshi 山口大学, 大学院医学系研究科, 助教 (70448281)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: hydrocephalus / risk factor / hypertension / rat

Outline of Final Research Achievements

Objective: In hydrocephalus state, cerebrospinal fluid (CSF) does not enlarge subarachnoid space but cerebral ventricles. In the present study, the hypothesis that pulsation of intraventricular arteries expands the ventricles was investigated. Methods: Spontaneous hypertensive rat (SHR) and normotensive Wistar rat were subjected for the study. Kaolin was injected into the basal cisterns to develop hydrocephalus. The ventricular size was measured two weeks later. Results: Ventricle width / brain width of SHR is 48 ± 12%, which was significantly larger than 39 ± 12% of the Wistar rat (p = 0.04). Conclusion: Hypertensive rat indicated ventricular enlargement in larger extent than normotensive rat. Hypertension could be one of the reason to enlarge ventricular size.

Free Research Field

Neurosurgery