2016 Fiscal Year Final Research Report
Development of an intraoperative molecular probe visualizing the focal cortical dysplasia
| Project/Area Number |
25462269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 分子イメージング / 限局性皮質形成異常 / てんかん手術 / 術中支援システム |
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| Outline of Final Research Achievements |
We performed immunohistochemical analysis on the tissue resected form the patients with neocortical epilepsy during the study period. Immunoblot was performed for the cerebrospinal fluid (CSF) obtained during epilepsy- and control surgeries. We thereby selected candidate target proteins of molecular probes that would visualize the extent of FCD during surgery. The candidate target molecules would be extracellular secreted proteins, TGFβ and chromogranin A, to construct molecular probes visualizing the FCD tissue. Intraoperative fluorescent-labeled molecular probes would enhance spacial resolution to localize the epileptic focus and thereby improve surgical outcome of neocortical epilepsy.
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| Free Research Field |
脳神経外科
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