2016 Fiscal Year Final Research Report
Tumor suppression of glioma by electric stimulation
| Project/Area Number |
25462271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 悪性神経膠腫 / 電場変容 / パルス電流 / ヌードマウス |
|---|
| Outline of Final Research Achievements |
Modulation of electric field is a new treatment modality of malignant glioma. U87 glioma cells were injected beneath the skin of nude mouse (ICR-nu). The tumor grew to 2 cm in diameter within 40 days. The stimulation electrode was inserted into the tumor, then electric stimulation was applied for 30 minutes. Two days after the electric stimulation, the tumor was removed and prepared for histological examinations. H-E, MIB-1, and TUNEL staining revealed the morphological changes of the tumor cells and alteration of inflamatory cells. Based on the result of this study, we elaborate a plan by clinical application to malignant glioma treatment located in the brainstem in the future.
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| Free Research Field |
脳神経外科
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