2016 Fiscal Year Final Research Report
Basic research of DDS therapy for malignant brain tumor
| Project/Area Number |
25462274
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
Kuroda Junichiro 熊本大学, 大学院生命科学研究部(医), 助教 (90536731)
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| Research Collaborator |
MATSUMURA Yasuhiro
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | brain tumor / drug delivery system / tissue factor / antibody / ADC |
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| Outline of Final Research Achievements |
We focused on brain tumor cell factor and tumor tissue environmental factor to develop DDS therapy for malignant brain tumor.Tissue factor is one of the trigger molecule for exogenous coagulation in malignant tumor. We examined drug delivery method using anti tissue factor factor monoclonal antibody. First of all, immunostaining of glioma was carried out, and it was confirmed that tissue factor was highly expressed as malignancy increased. Next, we conducted animal experiments in which the glioblastoma cell line was transplanted subcutaneously, and it was confirmed that the anti-tissue factor antibody highly accumulated in the tumor and did not accumulate in normal organs. It is expected to develop into an antibody drug complex using tissue factor antibody.
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| Free Research Field |
brain tumor
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