2013 Fiscal Year Research-status Report
下垂体腺腫におけるGremlinの発現と細胞内シグナルの解析に関する研究
| Project/Area Number |
25462279
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| Research Institution | Nippon Medical School |
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Principal Investigator |
吉田 大蔵 日本医科大学, 医学部, 准教授 (30210701)
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| Co-Investigator(Kenkyū-buntansha) |
金 景成 日本医科大学, 医学部, 助教 (30339387)
太組 一朗 日本医科大学, 医学部, 講師 (60307923)
森田 明夫 日本医科大学, 医学(系)研究科(研究院), 教授 (60302725)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | angiogenesis / Gremlin / pitutary adenoma / tissue microarray |
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| Research Abstract |
The purpose of the present study is to investigate the role of Gremlin focused on tumor angiogenesis in pituitary adenoma.
Double fluorescence immunohistochemistry of Gremlin and CD34 to elucidate distribution in pituitary adenoma tissues obtained by transsphenoidal surgery in 45 cases (7 PRL-oma, 17 GH-oma, 17, 2 ACTH-oma, and 2 TSH-oma). Expression of CD34-positve vessels was significantly co-related to that of Gremlin. Co-localization of Gremlin and CD34 was statistically significant. Subsequently, Gremlin and microvascular density (MVD) were detected by double-immunofluorescence microscopy in CD34-positive vessels from tissue microarray analysis in 61 cases with pituitary adenomas. In tissue microarray analysis, MVD were significantly increased along with increased Gremlin. Meanwhile, adenoma subtype and Knosp grading were not related to Gremlin.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
下垂体腺腫における発現分布と血管新生のとの有意な関連が得られたため
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| Strategy for Future Research Activity |
Gremlinのシグナルの下流域についてさらに研究をすすめる。
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