Elucidation of the pain processing mechanism in the brain using Default mode network analysis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462280
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Meiji University of Integrative Medicine
• Principal Investigator: TANAKA CHUZO 明治国際医療大学, 医学教育研究センター, 名誉教授 (80163541)
• Co-Investigator(Kenkyū-buntansha): HIGUCHI TOSHIHIRO 明治国際医療大学, 医学教育研究センター, 教授 (80218700) ; UMEDA MASAHIRO 明治国際医療大学, 医学教育研究センター, 教授 (60223608)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 疼痛 / fMRI

Outline of Final Research Achievements

It is the experiments which analyzed the brain function of a chronic low back pain using the f-MRI and default mode network (DMN). AKA-Hakata method, one of arthrokinematic approach (AKA) in Japan is used as treatment for pain relief. After anatomical and rs-fMRI measurements, all participants periodically received passive intra-articular movement in the right talono-vicular joint for a fMRI of the block paradigm. After the treatment, the anatomical, rs-fMRI, and block paradigm fMRI measurements were performed again. The modulatory effect of pain-relief manipulation therapy to the somatosensory evoked different response in S1 and DMN on chronic lumbago patients. It might be sustained attentional change or shift due to diminish painful sensation of lumbago after treatment, which is not synchronized passive intra-articular movement task, was caused disappearance activation.

Free Research Field

脳神経外科学