Animal model of adolescent idiopathic scoliosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462296
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyushu University
• Principal Investigator: DOI TOSHIO 九州大学, 大学病院, 准教授 (60346799)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 側弯症 / 思春期 / 動物モデル / 胸郭

Outline of Final Research Achievements

Adolescent Idiopathic Scoliosis, which dramatically worsens in the adolescent period, is characterized by the features of right thoracic scoliosis. To date, a variety of pathogenic factors have been proposed as a cause of idiopathic scoliosis, however, the cause remains unclear. One of the factors limiting elucidating the treatment method of idiopathic scoliosis has been the lack of a relevant animal model. We found that the anteroposterior chest dimension in patients with thoracic scoliosis was significantly smaller than that in normal people. By applying no surgical orthosis, we could established mouse model of scoliosis. In the future, we could develop a new concept orthosis or a new minimal invasive method for the treatment of scoliosis. Additionally, we found a new sagittal parameter to estimate the pelvic tilt, which is important for daily practice.

Free Research Field

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