2015 Fiscal Year Final Research Report
Analysis of the mechanism of intervertebral disc degeneration induced by passive cigarette smoking in rat model
| Project/Area Number |
25462313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nihon University |
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Principal Investigator |
UEI Hiroshi 日本大学, 医学部, 助教 (50451373)
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| Co-Investigator(Kenkyū-buntansha) |
TOKUHASHI Yasuaki 日本大学, 医学部, 教授 (80188739)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 椎間板変性 / 喫煙 / 脊椎脊髄病学 |
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| Outline of Final Research Achievements |
We performed a proteomic analysis of rat degenerative intervertebral discs induced by passive cigarette smoking. Expression of apoptosis-related genes were up-regulated. We also investigated the therapeutic effect of dedifferentiated fat (DFAT) cell transplantation by intravenous administration in rat models of intervertebral disc degeneration. The results suggest that autologous implantation of DFAT cells suppress down-regulated expression of intervertebral disc genes.
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| Free Research Field |
脊椎脊髄病学
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