2016 Fiscal Year Final Research Report
Regulation of malignant bone and soft-tissue tumor metastasis and invasion via cell morphology, glucose metabolism and microenvironment.
| Project/Area Number |
25462322
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gunma University |
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Principal Investigator |
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| Research Collaborator |
FUNASAKA Tatsuyoshi 金沢大学, フロンティアサイエンス機構
Raz Avraham Karmanos Cancer Institute
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 細胞形態 / 細胞運動 / 転移 / 浸潤 / 肉腫 |
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| Outline of Final Research Achievements |
Human fibrosarcoma cell line HT-1080 shows both mesenchymal and amoeboid migrations in 3D collagen gel cell culture system. We revealed that autocrine motility factor (AMF) changed the cells showing mesenchymal shape into amoeboid type via RhoA activation. Glucose metabolism did not affect the morphological change, although AMF is also important for glucose metabolism not for cell migration.
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| Free Research Field |
整形外科
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