2015 Fiscal Year Final Research Report
Analysis of Osteochondroma Formation Using Prx1Cre ERT; Ext1flox/flox mice
| Project/Area Number |
25462326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gifu University |
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Principal Investigator |
Ito Yoshiki 岐阜大学, 医学(系)研究科(研究院), 非常勤講師 (10313884)
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| Co-Investigator(Kenkyū-buntansha) |
Kazu Matsumoto 岐阜大学, 医学系研究科, 准教授 (40422711)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 多発性外骨腫症 |
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| Outline of Final Research Achievements |
Multiple hereditary exostosis (MHE) is autosomal dominant disorder characterized by multiple osteochondroma formation and deformities of extremities due to osteochondroma formation. To determine the function of heparin sulfate in the perichondrium, we have generated Prx1-CreER; Ext1flox/flox mice (Cre mice) by breeding the Prx1-CreER transgenic mice with the Ext1flox/flox mice. EXT1 expression was deleted in the perichondrium due to tamoxifen injection after birth, and Cre mice exhibited the osteochondroma formation in the extremities.
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| Free Research Field |
骨関節疾患
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