Development of boron neutron capture therapy (BNCT) for metastatic lung clear cell sarcoma.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462330
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: Fujimoto Takuya 神戸大学, 医学部附属病院, 医学研究員 (00397811)
• Co-Investigator(Kenkyū-buntansha): ICHIKAWA Hideki 神戸学院大学, 薬学部, 教授 (00248105) ; SUZUKI Minoru 京都大学, 原子炉実験所, 特定准教授 (00319724) ; AKISUE Toshihiro 神戸大学, 保健学研究科, 教授 (90379363)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ホウ素中性子捕捉療法 / 明細胞肉腫 / 肺転移 / 担がん動物モデル / 全肺照射

Outline of Final Research Achievements

Clear cell sarcoma (CCS) of tendons and aponeuroses is a rare malignant tumor of poor prognosis, with a predilection for young adults. Its standard treatment is still wide surgical resection, since neither chemotherapy nor radiotherapy is effective. Furthermore, in the course of treatment, CCS often metastasizes to the lung, and such tumors are, at present, not even amenable to surgical resection. In this study, therefore, boron neutron capture therapy (BNCT) was evaluated through the treatment of lung metastasis in a human CCS-bearing animal model. Here, for the first time, the results showed that the metastatic CCS tumor mass in the lung of the animal model was selectively destroyed by subjecting the whole lung to the irradiation involved in BNCT, which demonstrates great potential as a new option for the treatment of human metastatic lung CCS.

Free Research Field

骨・軟部腫瘍