2015 Fiscal Year Final Research Report
New Strategy for the Treatment of Fracture Nonunion with CD34-positive Cell Transplantation
| Project/Area Number |
25462331
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Takehiko 神戸大学, 医学部付属病院, 助教 (40467650)
KURODA Ryosuke 神戸大学, 医学(系)研究科(研究院), 准教授 (80379362)
KUROSAKA Masahiro 神戸大学, 医学(系)研究科(研究院), 教授 (70170115)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | CD34陽性細胞 / 偽関節 |
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| Outline of Final Research Achievements |
Phase 1/2 Clinical trial of CD34-positive cell transplantation for patients with fracture nonunion was successfully performed. However, more effective way should be explored. Therefore, we examined 2 new strategies for this treatment. The first results proved that transplantation of AteloGene with Lnk si RNA contributed to ealry healing of mouse fracture model.
The second results proved that ex-vivo expanded CD34-positive cells with key growth factors improved the efficacy by in vitro expansion culture and in vivo xenotransplantation model (human cell-immunodeficient rat).
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| Free Research Field |
整形外科学
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