Biomaterial mechanical characters and environmental factors influencing biofilm formation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462340
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Nagasaki University
• Principal Investigator: YODA Itaru 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (40646775)
• Co-Investigator(Kenkyū-buntansha): KOSEKI Hironobu 長崎大学, 医歯薬学総合研究科(医学系), 教授 (70457571) ; OSAKI Makoto 長崎大学, 医歯薬学総合研究科(医学系), 教授 (20380959)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 感染 / バイオフィルム / 生体人工材料

Outline of Final Research Achievements

When bacteria form biofilm on biomaterial surface, chemo-therapy with antibiotics is difficult, and surgeries for implant-related infection are required. We evaluated the efficacy of mechanical charactors of biomaterial and environmental factors inhibiting biofilm formation. The smooth and hydrophobic surface of biomaterial obstructed bacterial adherence. In addition to that, biofilm formation was inhibited in albumin rich environment at lower temperature. These finding will help us to prevent a postoperative implant-related infection and to treat the suffered patients.

Free Research Field

感染症