2015 Fiscal Year Final Research Report
Effect of parathyroid hormone on chondrogenic differentiation from mesenchymal stem cells
| Project/Area Number |
25462347
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
KUMAGAI Ken 横浜市立大学, 医学部, 講師 (10468176)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAITO Tomoyuki 横浜市立大学, 医学研究科, 教授 (30170517)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 軟骨分化 / PTH / 間葉系幹細胞 |
|---|
| Outline of Final Research Achievements |
The present study demonstrated that chondrogenic differentiation of Mesenchymal stem cells (MSCs) was modulated by parathyroid hormone (PTH). The results revealed that PTH has opposite effects on chondrogenesis when administered at different concentrations. Namely, low to moderate concentrations of PTH promoted chondrogenic differentiation of MSCs, whereas chondrogenesis of MSCs was inhibited and not stimulated by a higher concentration of PTH. Based on clinical experience with the efficacy and safety of PTH for bone metabolism, PTH may also be useful clinically for cartilage repair.
|
| Free Research Field |
医歯薬学
|
